From the help file:
Use Video Card YUV Acceleration: This option enables causes VideoReDo to request that your video card convert the MPEG signal from its native YUV format to the computer screen's RGB format. Most modern video cards support YUV hardware acceleration. Choosing this option will often result in a slightly better picture quality, and will reduce the CPU usage of VideoReDo by 5% to 15%. If you select this option, but VideoReDo is unable to take advantage of this feature, then VideoReDo will revert, temporarily, to non-accelerated mode. A message indicating this has happened is written to the log file. For slower machines CPUs (less than 1GHz), enabling YUV acceleration can have a dramatic improvement of VideoReDo's interactive response.
Note: If VideoReDo detects that you are editing HD material it will attempt to automatically enable YUV acceleration regardless of this setting. If you have multiple monitors on your system, you might want to disable the YUV acceleration mode as VideoReDo only supports YUV acceleration on the primary monitor. You will not be able to see your video picture on other monitors when using this mode.
When you display interlaced video you are are seeing both fields simultaneously which can give you the "edgecomb" effect. Do a Google search for examples and further explanation.